Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation

ArticleHAEMATOLOGICA-THE HEMATOLOGY JOURNAL. 92(1-11): 1576-1578 (2007)journal articl

Arthroscopic management of temporomandibular closed lock

The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included

Design and performance of the muon monitor for the T2K neutrino oscillation experiment

This article describes the design and performance of the muon monitor for the T2K (Tokaito-Kamioka) long baseline neutrino oscillation experiment. The muon monitor consists of two types of detector arrays: ionization chambers and silicon PIN photodiodes. It measures the intensity and profile of muons produced, along with neutrinos, in the decay of pions. The measurement is sensitive to the intensity and direction of the neutrino beam. The linearity and stability of the detectors were measured in beam tests to be within 2.4% and 1.5%, respectively. Based on the test results, the precision of the beam direction measured by the muon monitor is expected to be 0.25 mrad.Comment: 22 page

Serum levels of free light chain before and after chemotherapy in primary systemic AL amyloidosis

This is an electronic version of an article published in AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 13: 71(2006) [AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS] is available online at: http://www.informaworld.com/openurl?genre=article&issn=1350-6129&volume=13&issue=3&spage=71ArticleAmyloid-Journal of Protein Folding Disorders. 13(Suppl. 1): 45-45 (2006)journal articl

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

advance online publication, February 25, 2014Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways, inactivation of the NF1 or mutations in PTPN11, NRAS, KRAS and CBL. A whole-exome sequencing study, performed by Sakaguchi et al.,3 has recently demonstrated that in addition to the high frequency of RAS pathway mutations, mutations in SETBP1 and JAK3 are common recurrent secondary events, and that these events may be involved in tumor progression, and are associated with poor clinical outcomes.ArticleLEUKEMIA. 28(7):1545-1548 (2014)journal articl

Development and operational experience of magnetic horn system for T2K experiment

A magnetic horn system to be operated at a pulsed current of 320 kA and to survive high-power proton beam operation at 750 kW was developed for the T2K experiment. The first set of T2K magnetic horns was operated for over 12 million pulses during the four years of operation from 2010 to 2013, under a maximum beam power of 230 kW, and $6.63\times10^{20}$ protons were exposed to the production target. No significant damage was observed throughout this period. This successful operation of the T2K magnetic horns led to the discovery of the $\nu_{\mu}\rightarrow\nu_e$ oscillation phenomenon in 2013 by the T2K experiment. In this paper, details of the design, construction, and operation experience of the T2K magnetic horns are described.Comment: 22 pages, 40 figures, also submitted to Nuclear Instrument and Methods in Physics Research,

Drift field generation with Cockcroft-Walton voltage multiplier in xenon gas for AXEL 0vββ search detector

16th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2019) 9-13 September 2019, Toyama, JapanFor noble gas Time Projection Chambers (TPCs) in the field of rare event searches, operation of high voltage to generate an electric field is a key point. We designed a new structure of electrodes to shape a strong and uniform drift field without electric discharge, in which electrodes of two different radius are used. We also developed Cockcroft-Walton voltage multiplier as a high voltage generator inside a pressure vessel. We achieved −30.0 kV output and examined such kind of voltage generator is feasible as a high voltage supplier in a TPC